SBA — Single Best Answer · Review
Question 377
Pathology → General
Classification
Question
SSBAQuestion Header
A patient with impaired wound healing has a nutritional deficiency that specifically prevents conversion of proline to hydroxyproline and thereby interferes with collagen formation. Which deficiency best explains this abnormality?
Question Stem
Select the single best answer.
Options
A
Vitamin A
B
Vitamin C
C
Vitamin D
D
Vitamin K
E
Vitamin B12
Explanation
Vitamin C deficiency delays wound healing because it prevents conversion of proline to hydroxyproline and therefore impairs collagen formation.
Option Validity
A) Vitamin A deficiency can adversely affect healing, but it is not the deficiency as preventing proline-to-hydroxyproline conversion.
C) Vitamin D is not the specified cofactor in this collagen-forming step.
D) Vitamin K is primarily associated with synthesis of coagulation factors rather than this collagen modification.
E) Vitamin B12 deficiency is not the cause of failure of proline hydroxylation described here.
Further Reading
Saxena R. Textbook for MRCOG-1. Chapter 5: Pathology. General Pathology, pp.161–175.