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Question 392
Pathology → General
Classification
Question
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An acute inflammatory lesion develops substantial tissue necrosis rather than minimal tissue damage. Neutrophils accumulate and liquefaction of the damaged tissue follows. Which outcome is most consistent with this pattern?
Question Stem
Select the single best answer.
Options
A
Complete resolution without tissue destruction
B
Immediate regeneration without an inflammatory response
C
Pus formation with development of an abscess
D
Primary union
E
Metaplasia
Explanation
The outcome of acute inflammation depends partly on the extent of tissue destruction. Minimal destruction may permit resolution, whereas substantial tissue necrosis may lead to pus formation and development of an abscess. Persistent infection or extensive destruction may subsequently lead to chronic inflammation.
Option Validity
A) Resolution is favoured when tissue destruction is minimal rather than substantial.
B) The scenario describes an established acute inflammatory response with significant necrosis.
D) Primary union describes healing of a clean, approximated wound and is not the immediate outcome described here.
E) Metaplasia is an adaptive change in differentiated cell type rather than an outcome of this acute inflammatory lesion.
Further Reading
Saxena R. Textbook for MRCOG-1. Chapter 5: Pathology. General Pathology, pp.161–175.