SBA — Single Best Answer · Review
Question 396
Pathology → General
Classification
Question
SSBAQuestion Header
A woman was exposed in utero to a synthetic oestrogen that was previously prescribed during pregnancy. Which later malignancy is specifically associated with this prenatal exposure?
Question Stem
Select the single best answer.
Options
A
Hepatocellular carcinoma
B
Kaposi sarcoma
C
Vaginal clear-cell carcinoma
D
Nasopharyngeal carcinoma
E
Mesothelioma
Explanation
Prenatal exposure to diethylstilbestrol (DES) is associated with subsequent development of clear-cell carcinoma of the vagina. This among important environmental and exposure-related predispositions to malignancy.
Option Validity
A) Hepatocellular carcinoma is associated with factors including hepatitis B and hepatitis C infection rather than prenatal DES exposure.
B) Kaposi sarcoma is associated with HHV8.
D) Nasopharyngeal carcinoma is associated with Epstein-Barr virus.
E) Mesothelioma is associated with asbestos exposure.
Further Reading
Saxena R. Textbook for MRCOG-1. Chapter 5: Pathology. General Pathology, pp.161–175.