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Question 399
Pathology → General
Classification
Question
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A patient with recurrent thrombosis is being investigated for an inherited thrombophilic state. Which combination consists entirely of inherited abnormalities listed as causes of thrombophilia?
Question Stem
Select the single best answer.
Options
A
Antithrombin III deficiency, protein C deficiency and protein S deficiency
B
Protein C deficiency, chronic inflammation and systemic infection
C
Protein S deficiency, atherosclerosis and hypertension
D
Antithrombin III deficiency, obesity and smoking
E
Protein C deficiency, diabetes mellitus and hypercholesterolaemia
Explanation
Inherited thrombophilic states include antithrombin III deficiency, protein C deficiency and protein S deficiency, as well as abnormalities such as factor V Leiden, dysplasminogenaemia, dysfibrinogenaemia and heparin cofactor II deficiency.
Option Validity
B) Chronic inflammation and systemic infection are not inherited thrombophilic abnormalities.
C) Atherosclerosis and hypertension are vascular risk factors rather than inherited thrombophilias in this list.
D) Obesity and smoking are not inherited coagulation abnormalities.
E) Diabetes mellitus and hypercholesterolaemia are not inherited thrombophilic defects of the type requested.
Further Reading
Saxena R. Textbook for MRCOG-1. Chapter 5: Pathology. General Pathology, pp.161–175.