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Question 402
Pathology → General
Classification
Question
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An inflammatory exudate forms after acute tissue injury. In addition to immunoglobulins and antibacterial factors, fibrinogen enters the extravascular tissue. Which consequence best explains the contribution of fibrin formation to the local inflammatory response?
Question Stem
Select the single best answer.
Options
A
It converts the inflammatory exudate into a low-protein transudate
B
It helps form a local barrier, contributes to tissue union and facilitates phagocytosis
C
It prevents leucocyte margination by increasing blood flow
D
It abolishes vascular permeability and terminates inflammation immediately
E
It prevents macrophage entry into damaged tissue
Explanation
Protein-rich inflammatory exudate contains fibrinogen as well as immunoglobulins and antibacterial factors. Conversion of fibrinogen to fibrin contributes to localisation of the inflammatory process, tissue union and facilitation of phagocytosis.
Option Validity
A) An inflammatory exudate remains protein rich and is distinct from a low-protein transudate.
C) Fibrin does not prevent the leucocyte sequence of margination, adhesion and emigration.
D) Fibrin formation does not abolish vascular permeability or immediately terminate inflammation.
E) Macrophages participate in removal of damaged tissue; fibrin does not characteristically prevent their entry.
Further Reading
Saxena R. Textbook for MRCOG-1. Chapter 5: Pathology. General Pathology, pp.161–175.