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Question 404
Pathology → General
Classification
Question
SSBAQuestion Header
Several days after tissue injury, the wound contains proliferating fibroblasts, newly formed capillaries and developing extracellular matrix. Which component of the repair process is most directly represented by the proliferation and activity of fibroblasts?
Question Stem
Select the single best answer.
Options
A
Margination
B
Fibroplasia
C
Metaplasia
D
Caseation
E
Pavementing
Explanation
Repair includes contraction, fibroplasia, angiogenesis and epidermal ingrowth. Fibroblasts proliferate and synthesize collagen and mucopolysaccharides; together with capillary budding this contributes to vascular granulation tissue and subsequent scar formation.
Option Validity
A) Margination is an early leucocyte event in acute inflammation rather than fibroblast proliferation during repair.
C) Metaplasia is replacement of one differentiated mature cell type by another.
D) Caseation is a form of necrosis associated particularly with tuberculosis.
E) Pavementing describes leucocyte positioning along the endothelium during acute inflammation.
Further Reading
Saxena R. Textbook for MRCOG-1. Chapter 5: Pathology. General Pathology, pp.161–175.