Question 412

Chronic inflammation may produce systemic manifestations including fever, anaemia, leucocytosis and raised ESR. Persistent chronic inflammatory activity may subsequently lead to secondary amyloidosis.

B) Disseminated intravascular coagulation is associated with major activation of coagulation, including severe septic shock, rather than the characteristic long-term systemic complication described.

C) Acute tubular necrosis is an organ consequence of severe circulatory shock rather than a characteristic consequence of longstanding chronic inflammation.

D) Caseous necrosis is a morphological pattern particularly associated with tuberculosis and does not represent the systemic complication described.

E) Polycythaemia is not a characteristic systemic consequence of chronic inflammation; anaemia is specifically recognised.

Saxena R. Textbook for MRCOG-1. Chapter 5: Pathology. General Pathology, pp.161–175.