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Question 457
Pharmacology → General
Classification
Question
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A beta-sympathomimetic drug produces bronchodilatation and uterine relaxation. Which additional pattern of effects is most consistent with the pharmacological profile?
Question Stem
Select the single best answer.
Options
A
Reduced renin release, glycogenesis and lipogenesis
B
Intestinal contraction, urinary tract contraction and reduced cardiac stimulation
C
Renin release, glycogenolysis, gluconeogenesis and lipolysis
D
Bronchoconstriction, uterine contraction and inhibition of gluconeogenesis
E
Reduced heart rate, reduced contractility and increased peripheral resistance
Explanation
Beta-sympathomimetic activity as producing bronchial and uterine relaxation together with relaxation of the intestinal and genitourinary walls. Other effects include cardiac stimulation, renin release, glycogenolysis, gluconeogenesis and lipolysis.
Option Validity
A) renin release and catabolic metabolic effects rather than reduced renin release with glycogenesis and lipogenesis.
B) Beta-sympathomimetic activity relaxes intestinal and genitourinary smooth muscle and stimulates the heart rather than producing the opposite pattern.
D) Bronchial and uterine relaxation, not constriction, are described; gluconeogenesis is stimulated rather than inhibited.
E) Positive chronotropic and inotropic cardiac effects are characteristic of beta-sympathomimetic activity, and skeletal-muscle vasodilatation may reduce total peripheral resistance.
Further Reading
Saxena R. Textbook for MRCOG-1. Chapter 12: Pharmacology. Adrenergic Agents, p.345.