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Question 563
Biochemistry → General
Classification
Question
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A cytoskeletal abnormality weakens the structural linkage between adjacent cells through desmosomes without directly disrupting ciliary movement or the actin–myosin system. Which component is most likely affected?
Question Stem
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Options
A
Microtubules
B
Intermediate filaments
C
Microfilaments
D
Centrioles
E
Ribosomes
Explanation
Intermediate filaments form a rope-like network extending from around the nucleus towards the cell periphery. They help maintain cellular shape and connect adjacent cells through desmosomes. Microtubules are associated with functions including ciliary movement, while microfilaments contain actin and myosin.
Option Validity
A) Microtubules participate in intracytoplasmic transport, chromosome separation and movement of structures such as cilia.
C) Microfilaments are contractile structures composed of actin and myosin.
D) Centrioles participate in mitotic-spindle organisation and chromosome movement.
E) Ribosomes are responsible for protein synthesis rather than desmosomal structural linkage.
Further Reading
Saxena R. Textbook for MRCOG-1: Basic Sciences in Obstetrics & Gynaecology. Chapter 4 — Cytoskeleton: Intermediate Filaments. Printed page 128.