SBA — Single Best Answer · Review
Question 610
Immunology → General
Classification
Question
SSBAQuestion Header
Which combination best characterises helper/inducer T lymphocytes?
Question Stem
Select the single best answer.
Options
A
CD8 positive with MHC class I restriction
B
CD3 negative with CD16 and CD56 positivity
C
Surface immunoglobulin positive with CR2 expression
D
CD8 positive cells that suppress B- and T-cell responses
E
CD4 positive with self-MHC class II restriction
Explanation
Helper/inducer T lymphocytes are CD4 positive and show self-MHC class II restriction. They promote T-cell and macrophage activity, help B-cell antibody responses and stimulate cell-mediated immunity.
Option Validity
A) CD8 positivity with MHC class I restriction characterises cytotoxic and suppressor T-cell functions rather than helper/inducer T cells.
B) CD3 negativity with CD16 and CD56 positivity characterises natural killer cells.
C) Surface immunoglobulin and CR2 are B-cell features.
D) CD8-positive suppressor T cells suppress B- and T-cell responses.
Further Reading
Saxena MRCOG-1 Basic Sciences — Immunology: T-lymphocyte functions, printed page 210.