SBA — Single Best Answer · Review
Question 384
Pathology → General
Classification
Question
SSBAQuestion Header
Following an appropriate proliferative stimulus, an organ enlarges through recruitment of resting cells into the cell cycle and an increase in parenchymal cell number. Which tissue has the capacity to undergo this hyperplastic response?
Question Stem
Select the single best answer.
Options
A
Cardiac muscle
B
Neuronal tissue
C
Liver
D
Skeletal muscle
E
Mature central nervous system neurons
Explanation
Hyperplasia results from an increase in cell number through recruitment of cells from the G0 resting phase into mitosis. Stable cells, including parenchymal cells of the liver, pancreas, kidney, adrenal and thyroid, retain this capacity. Permanent cells such as neurons and cardiac and skeletal muscle have little or no regenerative hyperplastic potential.
Option Validity
A) Cardiac muscle is classified as permanent tissue with little or no regenerative hyperplastic capacity.
B) Neurons are permanent cells and do not have the hyperplastic potential described.
D) Skeletal muscle is a permanent tissue with little or no regenerative hyperplastic growth.
E) Mature CNS neurons are permanent cells rather than stable cells capable of this proliferative response.
Further Reading
Saxena R. Textbook for MRCOG-1. Chapter 5: Pathology. General Pathology, pp.161–175.