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Question 385
Pathology → General
Classification
Question
SSBAQuestion Header
Histological examination of a chronically infected lesion demonstrates a localised area of tissue death containing friable, cheese-like material. Which pattern of necrosis best accounts for this appearance?
Question Stem
Select the single best answer.
Options
A
Coagulative necrosis
B
Liquefactive necrosis
C
Fat necrosis
D
Fibrinoid necrosis
E
Caseous necrosis
Explanation
Caseous necrosis is characterised by cheese-like material at the site of necrosis and is classically associated with infection by Mycobacterium tuberculosis.
Option Validity
A) Coagulative necrosis is a recognised type of necrosis but does not describe the characteristic cheese-like material specified here.
B) Liquefactive necrosis produces tissue liquefaction rather than the caseous appearance described.
C) Fat necrosis affects adipose tissue and does not correspond to the characteristic caseous morphology.
D) Fibrinoid necrosis is a distinct morphological pattern and does not produce the cheese-like appearance described.
Further Reading
Saxena R. Textbook for MRCOG-1. Chapter 5: Pathology. General Pathology, pp.161–175.