SBA — Single Best Answer · Review
Question 386
Pathology → General
Classification
Question
SSBAQuestion Header
A patient with an occult malignancy develops recurrent migratory episodes of venous thrombosis at different anatomical sites without local tumour invasion accounting for the vascular events. Which tumour-associated systemic manifestation is most consistent with this presentation?
Question Stem
Select the single best answer.
Options
A
Trousseau syndrome
B
Lambert-Eaton syndrome
C
Carcinoid syndrome
D
Syndrome of inappropriate antidiuretic hormone secretion
E
Hypertrophic osteoarthropathy
Explanation
Trousseau syndrome is a paraneoplastic thrombotic manifestation characterised by migratory thrombophlebitis and is associated with malignancies including pancreatic, lung and gastrointestinal cancers.
Option Validity
B) Lambert-Eaton syndrome is a neuromuscular paraneoplastic manifestation rather than migratory thrombosis.
C) Carcinoid syndrome is a different tumour-associated systemic syndrome and does not describe recurrent migratory venous thrombosis.
D) SIADH produces disordered water balance and is not the thrombotic syndrome described.
E) Hypertrophic osteoarthropathy and clubbing may accompany lung malignancy but do not account for migratory thrombophlebitis.
Further Reading
Saxena R. Textbook for MRCOG-1. Chapter 5: Pathology. General Pathology, pp.161–175.