SBA — Single Best Answer · Review
Question 409
Pathology → General
Classification
Question
SSBAQuestion Header
Several patients have chronic disorders associated with an increased risk of subsequent malignancy. Which pairing correctly matches a predisposing condition with its associated malignant transformation?
Question Stem
Select the single best answer.
Options
A
Barrett oesophagus — oesophageal malignancy
B
Ulcerative colitis — hepatocellular carcinoma
C
Atrophic gastritis — mesothelioma
D
Actinic keratosis — ovarian carcinoma
E
Cervical intraepithelial neoplasia — pancreatic carcinoma
Explanation
Barrett oesophagus is a recognised predisposing condition for subsequent oesophageal malignancy. Other premalignant or predisposing conditions are similarly associated with characteristic subsequent tumours.
Option Validity
B) Ulcerative colitis predisposes to colorectal malignancy rather than hepatocellular carcinoma.
C) Atrophic gastritis is associated with gastric malignancy rather than mesothelioma.
D) Actinic keratosis predisposes to squamous cell carcinoma rather than ovarian carcinoma.
E) Cervical intraepithelial neoplasia predisposes to cervical carcinoma rather than pancreatic carcinoma.
Further Reading
Saxena R. Textbook for MRCOG-1. Chapter 5: Pathology. General Pathology, pp.161–175.