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Question 419
Pathology → General
Classification
Question
SSBAQuestion Header
A young woman has a malignant ovarian germ-cell tumour. Which tumour marker is particularly associated with trophoblastic and non-seminomatous germ-cell tumours?
Question Stem
Select the single best answer.
Options
A
CA 15-3
B
Calcitonin
C
HCG
D
PSA
E
CEA
Explanation
HCG is associated with trophoblastic tumours and non-seminomatous germ-cell tumours. The other markers listed have different tumour associations.
Option Validity
A) CA 15-3 is associated with breast carcinoma.
B) Calcitonin is associated with medullary carcinoma of the thyroid.
D) PSA is associated with prostatic carcinoma.
E) CEA is associated particularly with malignancies including bowel, pancreas and breast rather than the germ-cell association tested here.
Further Reading
Saxena R. Textbook for MRCOG-1. Chapter 5: Pathology. General Pathology, pp.161–175.