SBA — Single Best Answer · Review
Question 430
Pathology → General
Classification
Question
SSBAQuestion Header
Following loss of functional tissue, an organ restores its cell population by recruitment of normally quiescent cells from G0 into the cell cycle. Which tissue has the greatest capacity for this response?
Question Stem
Select the single best answer.
Options
A
Cardiac muscle
B
Cerebral neurons
C
Mature myocardium
D
Skeletal muscle
E
Liver
Explanation
Hyperplasia involves an increase in cell number and may occur through recruitment of cells from G0 into the proliferative cycle. Stable tissues such as liver retain this capacity, whereas permanent cells such as neurons and cardiac muscle have little or no regenerative hyperplasia.
Option Validity
A) Cardiac muscle is composed of permanent cells with little or no regenerative hyperplastic capacity.
B) Neurons are permanent cells and have negligible regenerative hyperplastic capacity.
D) Skeletal muscle is included among tissues with little or no regenerative hyperplasia.
C) Mature myocardium has very limited proliferative capacity and responds principally through hypertrophy rather than regenerative hyperplasia.
Further Reading
Saxena R. Textbook for MRCOG-1. Chapter 5: Pathology. General Pathology, pp.161–175.