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Question 541
Biochemistry → General
Classification
Question
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Loss of an organelle impairs both beta-oxidation of fatty acids and detoxification of hydrogen peroxide. Which additional function would be most directly associated with the same organelle?
Question Stem
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Options
A
Formation of the mitotic spindle
B
Packaging proteins for secretion
C
Conversion of purines to uric acid
D
Synthesis of ribosomal subunits
E
Storage of chromosomal DNA
Explanation
Peroxisomes participate in beta-oxidation of fatty acids and hydrogen peroxide detoxification. They are also associated with conversion of purines to uric acid, gluconeogenesis, myelin formation and bile-acid synthesis.
Option Validity
A) Mitotic spindle formation is associated with the centrosome and microtubules.
B) Protein processing and packaging are Golgi functions.
D) Ribosomal components are associated with the nucleolus rather than peroxisomes.
E) Chromosomal DNA is located in the nucleus.
Further Reading
Saxena - MRCOG-1 Basic Sciences - Biochemistry, printed pp.125–126.