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Question 584

Genetics → General

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Classification

Speciality
Obstetrics and Gynaecology
Group
Basic
Title
Genetics
Topic
General
Subtopic 1
Deoxyribonucleic Acid
Subtopic 2
Cellular Genome Organisation
Subtopic 3
DNA Localisation and Replication
Question Type
SBA

Question

SSBA
Question Header
Which interpretation correctly identifies the two DNA distributions and the chromosome-copying process?
Question Stem
Two cell preparations are fractionated. Material containing deoxyribose and thymine is found mainly in nuclear chromatin in preparation 1 and mainly in the cytoplasm in preparation 2. Material containing ribose and uracil is measured separately to avoid confusing RNA with the genomic DNA signal. The investigators then follow the copying of chromosome DNA before cell division.

Options

A Preparation 1 shows a prokaryotic DNA distribution, preparation 2 a eukaryotic distribution, and chromosome copying is replication
B Preparation 1 shows a eukaryotic DNA distribution, preparation 2 a prokaryotic distribution, and chromosome copying is replication
C Preparation 1 shows a eukaryotic DNA distribution, preparation 2 a prokaryotic distribution, and chromosome copying is transcription
D Preparation 1 shows a eukaryotic DNA distribution, preparation 2 a prokaryotic distribution, and chromosome copying is translation
E The deoxyribose-and-thymine material is RNA in both preparations, and its copying identifies translation

Explanation

Deoxyribose and thymine identify the DNA-containing material, whereas ribose and uracil identify RNA. Most eukaryotic DNA is nuclear and packaged as chromatin, although some is present in organelles such as mitochondria. Prokaryotic DNA is mainly cytoplasmic. These distributions therefore fit preparations 1 and 2 respectively. Copying chromosome DNA before cell division is DNA replication, distinct from making an RNA transcript or synthesising a polypeptide.

Option Validity

A) This reverses the characteristic distributions: predominantly nuclear chromatin is eukaryotic, whereas predominantly cytoplasmic DNA is prokaryotic.

C) The cell distributions are correctly identified, but transcription creates an RNA copy from DNA rather than duplicating chromosome DNA.

D) Translation uses mRNA to direct polypeptide synthesis; it is not chromosome duplication.

E) Deoxyribose and thymine identify DNA. RNA contains ribose and uracil, and translation produces a polypeptide rather than copying either nucleic acid.

Further Reading

Saxena R. Textbook for MRCOG-1: Basic Sciences in Obstetrics and Gynaecology. Jaypee Brothers Medical Publishers; 2016. Chapter 8, Genetics: Deoxyribonucleic Acid and Process of Protein Synthesis. Printed pages 254–255.

Source & metrics

Authored Difficulty
4.00
Evaluation Score
—
Destination
Site
Source
Saxena - MRCOG-1 Basic Sciences - Genetics
Source Section
Chapter 8 — Genetics; Deoxyribonucleic Acid
Source Locator
Printed pages 254–255
Updated
2026-10-06 01:57:35
Difficulty Factor
Not available yet
Attended Users
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