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Phagocytes, Dendritic Cells & Mast Cells

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Facts & Figures #93 — Edit

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Circulating monocytes migrate into tissues and differentiate into macrophages.
Macrophages are major phagocytic and antigen-presenting cells and can be activated by interferon-gamma.
Opsonisation is enhanced by C3b and the Fc portions of IgG1 and IgG3 and is not MHC restricted.
Neutrophils are actively phagocytic and predominate in acute inflammation.
Eosinophils participate particularly in extracellular killing of large parasites and occur in allergic inflammation and around antigen-antibody complexes.
Dendritic cells are bone-marrow-derived antigen-presenting cells distinct from macrophage and T/B-cell lineages.
Dendritic cells express MHC class II but lack Fc receptors, sheep-RBC receptors and surface immunoglobulin.
Mast-cell granules contain inflammatory mediators including histamine, heparin, serotonin and leucotrienes.
Mast-cell degranulation can be triggered by tissue injury, drugs, complement activation and foreign antigenic material.
Anaphylaxis following re-exposure in a sensitised individual is described as an IgE-mediated immune response.

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Classification Relationships — through Subtopic3

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Obstetrics and gynaecology→ Basic→ Immunology→ General→ Immune Cells→ Phagocytic Cells→ Antigen-Presenting Cells

Obstetrics and gynaecology→ Basic→ Immunology→ General→ Immune Cells→ Phagocytic Cells→ Granulocytes

Obstetrics and gynaecology→ Basic→ Immunology→ General→ Immune Cells→ Phagocytic Cells→ Monocytes and Macrophages

Obstetrics and gynaecology→ Basic→ Immunology→ General→ Immune Cells→ Phagocytic Cells→ Opsonisation

Phagocytes, Dendritic Cells & Mast Cells

Facts & Figures #93 — Edit

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Classification Relationships — through Subtopic3

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